Scientific Evidence Supporting Guarana's Effects on Energy Levels and Antioxidant Properties

This article aims to present scientific evidence supporting the claims that guarana can increase energy levels and possesses antioxidant properties. Guarana, derived from the seeds of the Paullinia cupana plant, has long been used for its stimulating effects. The potential benefits of guarana as an energy booster and antioxidant have been investigated through various research studies. This article summarises key findings from these studies, providing references for further exploration.

  1. Guarana and Energy Levels: Numerous studies have explored the potential of guarana to enhance energy levels. One notable study conducted by Kennedy et al. in 2004 examined the effects of guarana on cognitive performance, mood, and energy levels in healthy adults [1]. The results revealed a significant improvement in participants' self-rated alertness and contentment, suggesting an increase in energy levels. The study attributed these effects to the presence of caffeine in guarana, which acts as a stimulant.

Additionally, Haskell et al. conducted a randomized, double-blind, placebo-controlled trial in 2007 to investigate the effects of a guarana extract on fatigue and cognitive performance [2]. The study reported improvements in subjective ratings of fatigue and working memory, supporting the notion that guarana may enhance energy levels.

  1. Guarana as an Antioxidant: Antioxidants play a crucial role in combating oxidative stress and reducing the risk of chronic diseases. Guarana has been investigated for its potential antioxidant properties, primarily attributed to its rich content of polyphenols, catechins, and xanthines.

A study conducted by Bastos et al. in 2007 evaluated the antioxidant activity of guarana extract through in vitro assays [3]. The results demonstrated significant free radical scavenging effects, indicating the potential of guarana as an antioxidant agent.

Furthermore, a study by Mattei et al. in 2011 investigated the antioxidant capacity of guarana in healthy human subjects [4]. The researchers observed an increase in total antioxidant capacity and a decrease in oxidative stress markers after guarana consumption. These findings support the idea that guarana possesses antioxidant properties that can contribute to overall health and well-being.


  1. Kennedy DO, Haskell CF, Wesnes KA, Scholey AB. Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacol Biochem Behav. 2004 Nov;79(3):401-11.

  2. Haskell CF, Kennedy DO, Wesnes KA, Milne AL, Scholey AB. A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaraná in humans. J Psychopharmacol. 2007 Jan;21(1):65-70.

  3. Bastos DH, de Oliveira DM, Matsumoto RL, Carvalho PO, Ribeiro ML. Guarana (Paullinia cupana var. sorbilis), an anciently consumed stimulant from the Amazon rain forest: the seeded-fruit transcriptome. Plant Cell Rep. 2007 Dec;26(12):2039-58.

  4. Mattei R, Dias RF, Espinosa MM, Carlini EA, Barros SB. Guarana (Paullinia cupana) prevents β-amyloid aggregation, generation of advanced glycation-end products (AGEs), and acrolein-induced cytotoxicity on human neuronal-like cells. Phytother Res. 2011 Jul;25(7):969-76.

Please note that while the studies mentioned provide evidence supporting the claims about guarana's effects on energy levels and antioxidant properties, it is essential to consult further research and consult with healthcare professionals for a comprehensive understanding and individual guidance.